(R)-(+)-SKF-38393 hydrochloride
Synonym(s):(R)-(+)-SKF38393 Hydrochloride - CAS 81702-42-3 - Calbiochem;Dopamine D₁/D₅ Receptor Partial Agonist, (R)-SKF-38393 Hydrochloride, SKF-38393, SKF38393, SKF 38393
- CAS NO.：81702-42-3
- Empirical Formula: C16H17NO2.ClH
- Molecular Weight: 291.776
- MDL number: MFCD00055189
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:57:41
What is (R)-(+)-SKF-38393 hydrochloride?
The Uses of (R)-(+)-SKF-38393 hydrochloride
(R)-(+)-SKF-38393 Hydrochloride is the active enantiomer of (±)-SKF-38393, a D1 dopamine receptor agonist.
The Uses of (R)-(+)-SKF-38393 hydrochloride
(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
What are the applications of Application
(R)-(+)-SKF-38393 hydrochloride is the active enantiomer of (±)-SKF-38393, a D1 dopamine receptor agonist
Biochem/physiol Actions
(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a?benzazepine derivative, exhibits anorectic effects.
Properties of (R)-(+)-SKF-38393 hydrochloride
| Melting point: | 244-246 °C |
| solubility | 0.1 M HCl: soluble1.2mg/mL |
| form | solid |
| color | off-white to light tan |
| optical activity | [α]22/D +16.1°, c = 1.2 in methanol(lit.) |
Safety information for (R)-(+)-SKF-38393 hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-(+)-SKF-38393 hydrochloride
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