(R)-(-)-Phenylsuccinic acid
- CAS NO.：46292-93-7
- Empirical Formula: C10H10O4
- Molecular Weight: 194.18
- MDL number: MFCD00065930
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:21:42
What is (R)-(-)-Phenylsuccinic acid?
Chemical properties
almost white fine powder
The Uses of (R)-(-)-Phenylsuccinic acid
(R)-Phenylsuccinic Acid is an intermediate used in the preparation of optically active succinic acid derivatives used as hypoglycemic agents.
Definition
ChEBI: 2-Phenylsuccinic acid is a member of benzenes and a monocarboxylic acid.
Purification Methods
Purify the acids by re-precipitation from alkali and recrystallisation from H2O. [Naps & Johns J Am Chem Soc 62 2450 1940, Fredga & Matell Bull Soc Chim Belg 62 47 1953, Wren & Williams J Chem Soc 109 572 1916.] The racemate [635-51-8] has m 166-168o, 168o after recrystallisation from H2O or MeCN. Its S-benzylisothiuronium salt has m 164-165o (from EtOH) [Griediger & Pedersen Acta Chem Scand 9 1425 1955]. [Beilstein 9 IV 3351.]
Properties of (R)-(-)-Phenylsuccinic acid
| Melting point: | 173-176 °C |
| Boiling point: | 290.62°C (rough estimate) |
| alpha | -175 º (c=1%, acetone) |
| Density | 1.2534 (rough estimate) |
| refractive index | 1.5430 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetone (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.60±0.10(Predicted) |
| color | White to Off-White |
| optical activity | [α]20/D 175±4°, c = 1% in acetone |
| BRN | 3201702 |
| CAS DataBase Reference | 46292-93-7(CAS DataBase Reference) |
Safety information for (R)-(-)-Phenylsuccinic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-(-)-Phenylsuccinic acid
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