R-IMPP
- CAS NO.：2133832-83-2
- Empirical Formula: C24H27N3O2
- Molecular Weight: 389.49
- MDL number: MFCD31544323
- Update Date: 2026-07-20 17:44:43
What is R-IMPP?
Description
(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 μM). It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels. (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation.
Properties of R-IMPP
| Boiling point: | 594.4±50.0 °C(Predicted) |
| Density | 1.186±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 1 mg/ml; DMSO: 10 mg/ml |
| form | A crystalline solid |
| pka | 9.14±0.10(Predicted) |
| color | Light yellow to yellow |
Safety information for R-IMPP
Computed Descriptors for R-IMPP
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