(R)-(-)-3-Chloro-1,2-propanediol
Synonym(s):(R)-α-Glycerol chlorohydrin
- CAS NO.：57090-45-6
- Empirical Formula: C3H7ClO2
- Molecular Weight: 110.54
- MDL number: MFCD00135169
- EINECS: 611-463-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-12 09:17:10
What is (R)-(-)-3-Chloro-1,2-propanediol?
Chemical properties
clear light yellow liquid
The Uses of (R)-(-)-3-Chloro-1,2-propanediol
(R)-(-)-3-Chloro-1,2-propanediol is used as a reagent in the synthesis of PA-824, which is a promising antituberculosis drug candidate that has been synthesized. It is also used in the manufacture of L-carnitine, which is a quaternary ammonium compound involved in metabolism in most mammals, plants, and some bacteria.
Definition
ChEBI: The (R)-stereoisomer of 3-chloro-1,2-propanediol.
Health Hazard
The toxicological evaluation revealed that (R)-(-)-3-Chloro-1,2-propanediol was genotoxic in humans and had anti-fertility effects in male rats. The discharge of this compound into wastewater might cause serious environmental hazards[1].
References
[1] Yun‐Xu Yang. “Practical and Efficient Utilisation of (R)-3-chloro-1,2-Propanediol in Synthesis of L-Carnitine.” Journal of Chemical Research-s 93 1 (2011): 371–372.
Properties of (R)-(-)-3-Chloro-1,2-propanediol
| Melting point: | -40°C |
| Boiling point: | 213 °C(lit.) |
| alpha | -0.9 º (neat) |
| Density | 1.321 g/mL at 20 °C(lit.) |
| vapor pressure | 0.04 mm Hg ( 25 °C) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | soluble in Chloroform, Methanol |
| form | clear liquid |
| pka | 13.28±0.20(Predicted) |
| color | Colorless to Brown |
| Specific Gravity | 1.322 |
| optical activity | [α]20/D 1°, neat |
| Water Solubility | soluble |
| BRN | 2202928 |
| CAS DataBase Reference | 57090-45-6(CAS DataBase Reference) |
Safety information for (R)-(-)-3-Chloro-1,2-propanediol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H290:Corrosive to Metals H301:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H351:Carcinogenicity H370:Specific target organ toxicity, single exposure H372:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P234:Keep only in original container. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-(-)-3-Chloro-1,2-propanediol
| InChIKey | SSZWWUDQMAHNAQ-VKHMYHEASA-N |
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