(R)-(-)-2-Amino-1-propanol

Synonym(s):D-Alaninol

CAS NO.：35320-23-1
Empirical Formula: C3H9NO
Molecular Weight: 75.11
MDL number: MFCD00064413
EINECS: 629-219-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is (R)-(-)-2-Amino-1-propanol?

Chemical properties

Colorless to light yellow liqui

The Uses of (R)-(-)-2-Amino-1-propanol

(R)-(-)-2-Amino-1-propanol has been used as a derivatizing agent for gossypol during the analysis of gossypol enantiomers in cottonseed by high-performance liquid chromatography.

What are the applications of Application

R)-(-)-2-Amino-1-propanol is used as a chiral intermediate for the synthesis of pharmaceutical products and agrochemicals. It acts as additives in health care products and animal feed. It is a amino alcohol obtained by reduction of d-alanine. This compound could be converted into the corresponding nonracemic adenine derivative (R)-9-(1-Methyl-2-hydroxyethyl)adenine through minor variations on the classic Montgomery sequence[1].
(R)-(-)-2-Amino-1-propanol

General Description

(R)-(-)-2-Amino-1-propanol is a chiral secondary amine.

References

[1] Jeffery A, et al. Synthesis of Acyclic Nucleoside and Nucleotide Analogues from Amino Acids: A Convenient Approach to a PMEA±PMPA Hybrid. Tetrahedron, 2000; 56: 5077-5083.

Properties of (R)-(-)-2-Amino-1-propanol

Melting point:	8 °C
Boiling point:	173-176 °C(lit.)
alpha	-17 º (c=neat)
Density	0.965
refractive index	n20/D 1.450(lit.)
Flash point:	183 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Oily Liquid
pka	12.88±0.10(Predicted)
color	Clear colorless to light yellow
Specific Gravity	0.965
optical activity	[α]19/D 18°, neat
Water Solubility	SOLUBLE
Sensitive	Hygroscopic
BRN	1718866
CAS DataBase Reference	35320-23-1(CAS DataBase Reference)
NIST Chemistry Reference	(R)-(-)-2-Amino-1-propanol(35320-23-1)

Safety information for (R)-(-)-2-Amino-1-propanol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.