(R)-1-Boc-3-Aminopiperidine
Synonym(s):(R)-1-Boc-3-piperidinamine;tert-Butyl (R)-3-amino-1-piperidinecarboxylate
- CAS NO.：188111-79-7
- Empirical Formula: C10H20N2O2
- Molecular Weight: 200.28
- MDL number: MFCD03094717
- EINECS: 628-472-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-12 09:16:02
What is (R)-1-Boc-3-Aminopiperidine?
Chemical properties
Yellow liquid
The Uses of (R)-1-Boc-3-Aminopiperidine
(R)-(-)-3-Amino-1-Boc-piperidine is used as an intermediate in the manufacture of various substances such as pharmaceuticals.
The Uses of (R)-1-Boc-3-Aminopiperidine
(R)-3-Amino-1-Boc-piperidine can be used to prepare a benzoxazepine derivative named (R)-7-(3,5-dimethoxyphenyl)-N-(piperidin-3-yl)-4-propionyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide, a potent CBP/P300 bromodomain inhibitor.
General Description
(R)-3-Amino-1-Boc-piperidine can be used as a precursor for the preparation of dipeptidyl peptidase IV inhibitors like linagliptin, alogliptin, and other antidiabetic agents.
Properties of (R)-1-Boc-3-Aminopiperidine
| Boiling point: | 277.3±33.0 °C(Predicted) |
| alpha | 28.5 º (c=1, DMF) |
| Density | 1.041±0.06 g/cm3(Predicted) |
| refractive index | 1.4730 |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), DMF (Slightly), DMSO (Slightly) |
| form | Liquid |
| pka | 10.35±0.20(Predicted) |
| color | Colorless to pale yellow |
| optical activity | [α]/D -28.5±2°, c = 1 in DMF |
| Water Solubility | Immiscible with water. |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1 |
| CAS DataBase Reference | 188111-79-7(CAS DataBase Reference) |
Safety information for (R)-1-Boc-3-Aminopiperidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-1-Boc-3-Aminopiperidine
| InChIKey | AKQXKEBCONUWCL-MRVPVSSYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC[C@@H](N)C1 |
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