QUINUCLIDINE

Synonym(s):1-Azabicyclo[2.2.2]octane;ABCO

CAS NO.：100-76-5
Empirical Formula: C7H13N
Molecular Weight: 111.18
MDL number: MFCD00006690
EINECS: 202-887-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-10-22 15:21:50

What is QUINUCLIDINE?

The Uses of QUINUCLIDINE

Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. It is employed to prepare quinine and alkaloids. It finds application as a ligand, which is useful in the studies of OsO4-catalyzed dihydroxylation of olefins. It plays an important role in the formation of onium salts used testing of PAC-antagonist activity.

Definition

ChEBI: Quinuclidine is a saturated organic heterobicyclic parent and a member of quinuclidines.

Hazard

A poison by ingestion and skin contact. Low toxicity by inhalation. A moderate skin and severe eye irritant.

Purification Methods

Crystallise it from diethyl ether. The hydrochloride has m 364-365o(dec) (from EtOH or n-BuOH), and the picrate has m 225o (from aqueous EtOH). [Beilstein 20 H 144, 20 II 71, 20 III/IV 1966, 20/4 V 335.]

Properties of QUINUCLIDINE

Melting point:	157-160 °C (lit.)
Boiling point:	198.35°C (rough estimate)
Density	0.8928 (rough estimate)
vapor pressure	1.5 mm Hg ( 20 °C)
refractive index	1.4500 (estimate)
solubility	H2O: very slightly soluble
form	powder to crystal
pka	10.87±0.33(Predicted)
color	White to Light yellow
Water Solubility	Soluble in alcohol, diethyl ether, water and organic solvents.
Sensitive	Air Sensitive
Merck	14,8081
BRN	103111
CAS DataBase Reference	100-76-5(CAS DataBase Reference)
EPA Substance Registry System	1-Azabicyclo[2.2.2]octane (100-76-5)

Safety information for QUINUCLIDINE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H310:Acute toxicity,dermal H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection.