QD-394

CAS NO.：2132411-21-1
Empirical Formula: C19H19N5O2
Molecular Weight: 349.39
Update Date: 2026-01-04 19:55:51

What is QD-394?

Biological Activity

QD-394 is an inducer of reactive oxygen species (ROS) production.1 It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.

References

1.Hu, S., Sechi, M., Singh, P.K., et al.A novel redox modulator induces a GPX4-mediated cell death that is dependent on iron and reactive oxygen speciesJ. Med. Chem.63(17)9838-9855(2020)

Properties of QD-394

Boiling point:	566.3±50.0 °C(Predicted)
Density	1.368±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF: 1 mg/lm,DMSO: 5 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml,Ethanol: 1 mg/lm,PBS (pH 7.2): slightly soluble
form	A crystalline solid
pka	7.92±0.42(Predicted)
color	Brown to black

Safety information for QD-394

Computed Descriptors for QD-394

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