PYRVINIUM PAMOATE

Description

Pyrvinium is a tasteless, odorless, bright orange to black, crystalline solid. It is insoluble in water or ether, slightly soluble in chloroform, and soluble in glacial acetic acid.

The Uses of PYRVINIUM PAMOATE

anthelmintic

The Uses of PYRVINIUM PAMOATE

Pyrvinium Pamoate is a potent noncompetitive inhibitor of the androgen receptor, with the application towards prostate cancer treatment. Antihelmintic.

Definition

ChEBI: Pyrvinium pamoate is a naphthoic acid. It has a role as an anticoronaviral agent.

Indications

The cation is the active part of the compound. Pyrvinium is used against pinworms (Enterobius).

brand name

Povan (Parke-Davis).

General Description

Odorless bright orange or orange-red to brownish red or almost black fluffy powder. Melting point 210-215°C. Insoluble in water. Tasteless.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

PYRVINIUM PAMOATE is light sensitive. Incompatible with strong oxidizing agents, strong acids and bases .

Fire Hazard

Flash point data for PYRVINIUM PAMOATE are not available; however, PYRVINIUM PAMOATE is probably combustible.

Biochem/physiol Actions

Pyrvinium pamoate is a potent androgen receptor inhibitor. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors that reside in the cytoplasm and activated by testosterone and dihydrotestosterone. AR inhibitors have potential therapeutic benefit in prostate cancer; competitive inhibitors and chemical castration methods have been discovered, but both therapies have undesirable side effects and/or resistance potential. A screen for non-competitive inhibitors was performed, resulting in the discovery of pyrvinium as an AR inhibitor. In comparison to competitive inhibitors, this compound does not bind to the ligand-binding domain of AR or block DNA occupancy by AR, but it inhibits AR-dependent gene expression via a distinct signaling mechanism. It is more potent than classical competitive AR antagonists and exhibits synergy with other AR inhibitors.

Side Effects

Occasional adverse reactions are blood dyscrasia and folic acid deficiency. Rare adverse reactions are rash, vomiting, convulsion, shock, photosensitivity, and headache.