Pyrrole-2-carboxylic acid

CAS NO.：634-97-9
Empirical Formula: C5H5NO2
Molecular Weight: 111.1
MDL number: MFCD00005219
EINECS: 211-221-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-14 09:55:04

What is Pyrrole-2-carboxylic acid?

Chemical properties

Light brown powder

The Uses of Pyrrole-2-carboxylic acid

Pyrrole-2-carboxylic acid is small amphoteric polar metabolite produced by many Streptomyces species, often co-produced with its dimer, pyrocoll. Pyrrole-2-carboxylic acid is an important dereplication standard in discovery, displaying a distinctive UV spectrum and a broad range of biological activities, albeit weak. More recently, pyrrole-2-carboxylic has demonstrated antiparasitic activity against Trypanosomes by selective proline racemase inhibition and has potent antifungal activity against Phytophthora.

The Uses of Pyrrole-2-carboxylic acid

Pyrrole-2-carboxylic Acid is a reagent used in the synthesis of potent small molecule inhibitors of severe acute respiratory syndrome (SARS) coronavirus. Also used in the synthesis of [2,3-c]pyridine-7-one scaffolds.

What are the applications of Application

Pyrrole-2-carboxylic acid, Streptomyces sp. is a metabolite produced by Streptomyces species that has antifungal properties

Definition

ChEBI: A pyrrolecarboxylic acid that is 1H-pyrrole carrying a carboxy substituent at position 2.

Properties of Pyrrole-2-carboxylic acid

Melting point:	204-208 °C (dec.) (lit.)
Boiling point:	340.3±15.0 °C(Predicted)
Density	0.862
refractive index	1.441-1.445
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol.
form	Powder
pka	4.45(at 20℃)
color	White to off-white to pale pink
BRN	80825
CAS DataBase Reference	634-97-9(CAS DataBase Reference)
NIST Chemistry Reference	Pyrrole-2-carboxylic acid(634-97-9)

Safety information for Pyrrole-2-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.