Pyridazine N-oxide
Synonym(s):Pyridazine 1-oxide
- CAS NO.：1457-42-7
- Empirical Formula: C4H4N2O
- Molecular Weight: 96.09
- MDL number: MFCD05742416
- EINECS: 200-001-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:10
What is Pyridazine N-oxide?
The Uses of Pyridazine N-oxide
Coupling partner in Pd-catalyzed direct arylation reactions.
What are the applications of Application
Pyridazine N-oxide is A coupling partner in Pd-catalyzed direct arylation reactions.
Purification Methods
Purify the oxide by distillation in a vacuum and by sublimation in vacuo. When a solution of the oxide in MeOH is treated with an aqueous solution of CuCl2, the [C4H4N2O]2—CuCl2-2H2O-complex (m 182-183o) is formed from which the oxide can be recovered . [Pollak et al. J Org Chem 35 2478 1970, Klinge et al. Recl Trav Chim, Pays Bas 95 21 1976, Ohsawa et al. Tetrahedron Lett 1979 1978, Koelsch & Gumprecht J Org Chem 23 1605 1958, Beilstein 23 III/IV 890.]
Properties of Pyridazine N-oxide
| Melting point: | 298-305 °C |
Safety information for Pyridazine N-oxide
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Pyridazine N-oxide
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