Pyranoridine phosphate
- CAS NO.：76748-86-2
- Empirical Formula: C29H35ClN5O6P
- Molecular Weight: 616.05
- MDL number: MFCD05863545
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-22 22:14:22
What is Pyranoridine phosphate?
The Uses of Pyranoridine phosphate
antimalarial
The Uses of Pyranoridine phosphate
Pyronaridine Phosphate is an antimalarial drug.
What are the applications of Application
Pyronaridine Tetraphosphate is an antimalarial agent
Biological Activity
pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1].
References
[1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31.
Properties of Pyranoridine phosphate
| Melting point: | 233-236° (dec) |
| storage temp. | 2-8°C |
| solubility | acetic acid: soluble5mg/mL |
| form | solid |
| color | Light yellow to yellow |
Safety information for Pyranoridine phosphate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H361:Reproductive toxicity |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Pyranoridine phosphate
| InChIKey | YKUQEKXHQFYULM-UHFFFAOYSA-N |
Pyranoridine phosphate manufacturer
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