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HomeProduct name listPSI-7977-13C-d3

PSI-7977-13C-d3

  • CAS NO.：2070009-25-3
  • Empirical Formula: C22H26D3FN3O9P
  • Molecular Weight: 533.46
  • Update Date: 2025-08-20 16:56:22
PSI-7977-13C-d3 Structural

What is PSI-7977-13C-d3?

Description

PSI-7977-13C-d3 is intended for use as an internal standard for the quantification of PSI-7977 by GC- or LC-MS. PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.

The Uses of PSI-7977-13C-d3

PSI-7977-13CD3 is the isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Properties of PSI-7977-13C-d3

storage temp.  Store at -20°C
solubility  DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.2 mg/ml
form  A solid

Safety information for PSI-7977-13C-d3

Computed Descriptors for PSI-7977-13C-d3

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