PROTAC FLT-3 degrader 1
- CAS NO.：2230826-81-8
- Empirical Formula: C52H61N9O9S2
- Molecular Weight: 1020.23
- MDL number: MFCD32705099
- Update Date: 2024-07-02 08:55:42
What is PROTAC FLT-3 degrader 1?
Biological Activity
PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1].
References
[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.
Properties of PROTAC FLT-3 degrader 1
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 150 mg/mL (147.03 mM; Need ultrasonic) |
| form | Solid |
| pka | 12.59±0.70(Predicted) |
| color | White to light yellow |
Safety information for PROTAC FLT-3 degrader 1
Computed Descriptors for PROTAC FLT-3 degrader 1
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