PROTAC ER Degrader-4
- CAS NO.：2361114-15-8
- Empirical Formula: C53H67F3N6O8S
- Molecular Weight: 1005.2
- MDL number: MFCD34469813
- Update Date: 2025-04-17 18:22:24
What is PROTAC ER Degrader-4?
Biological Activity
PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1]. PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1].
References
[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.
Properties of PROTAC ER Degrader-4
| Boiling point: | 1038.9±65.0 °C(Predicted) |
| Density | 1.254±0.06 g/cm3(Predicted) |
| pka | 13.54±0.46(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
Safety information for PROTAC ER Degrader-4
Computed Descriptors for PROTAC ER Degrader-4
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