Propargyl-PEG4-acid
Synonym(s):4,7,10,13-Tetraoxahexadec-15-ynoic acid;Propargyl-PEG4-CH2CO2H
- CAS NO.：1415800-32-6
- Empirical Formula: C12H20O6
- Molecular Weight: 260.28
- MDL number: MFCD22683284
- Update Date: 2026-02-03 20:41:04
What is Propargyl-PEG4-acid?
Description
Propargyl-PEG4-acid is a PEG reagent with an alkyne and a terminal carboxylic acid. The carboxylic acid reacts with primary amine groups with the help of activators (e.g. EDC, or HATU). The 4-unit PEG spacer increases hydrophilicity. The alkyne can participate in copper-catalyzed Click Chemistry.
The Uses of Propargyl-PEG4-acid
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of Propargyl-PEG4-acid
| Boiling point: | 388.0±37.0 °C(Predicted) |
| Density | 1.129±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| pka | 4.28±0.10(Predicted) |
| form | Viscous Liquid |
| color | Colorless to light yellow |
Safety information for Propargyl-PEG4-acid
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02 |
| GHS Hazard Statements |
H242:Self-reactive substances and mixtures; and Organic peroxides |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P234:Keep only in original container. P235:Keep cool. P240:Ground/bond container and receiving equipment. P370+P378:In case of fire: Use … for extinction. P403:Store in a well-ventilated place. |
Computed Descriptors for Propargyl-PEG4-acid
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