Pristinamycin IA
- CAS NO.：3131-03-1
- Empirical Formula: C45H54N8O10
- Molecular Weight: 866.96
- MDL number: MFCD30489790
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is Pristinamycin IA?
The Uses of Pristinamycin IA
One of the two major components of Pristinamycin (Pristinamycin IA and Pristinamycin IIA (or Virginiamycin M1-V673810).
The Uses of Pristinamycin IA
Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a syngergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Viriginiamycin B acts a syngergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.
What are the applications of Application
Virginiamycin B is a depsipeptide antibiotic
Definition
ChEBI: A cyclodepsipeptide that is (together with pristinamycin IIA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organis s including methicillin-resistant Staphylococcus aureus.
Contact allergens
Pristinamycin is a systemic antibiotic of the synergistins/ streptogramins class, composed of two subunits: pristinamycin IA and pristinamycin IIA. It induces several types of drug reactions such as maculo-papular exanthema, systemic dermatitis, or acute generalized exanthematous pustulosis. Some patients have been previously skin-sensitized by virginiamycin. Crossreactivity is expected to virginiamycin and to the associated dalfopristin and quinupristin.
Properties of Pristinamycin IA
| Melting point: | 198° |
| Boiling point: | 780.3°C (rough estimate) |
| alpha | D22 -57.5° (c = 0.25 in ethanol) |
| Density | 1.1881 (rough estimate) |
| refractive index | 1.6910 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | pKa 7.20±0.05(H2O,t =25,I=0.2(LiClO4)) (Uncertain) |
| form | Solid |
| color | Pale Yellow |
Safety information for Pristinamycin IA
Computed Descriptors for Pristinamycin IA
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