Previridicatumtoxin

CAS NO.：1379585-81-5
Empirical Formula: C30H33NO10
Molecular Weight: 567.59
Update Date: 2025-04-17 18:22:24

What is Previridicatumtoxin?

Biological Activity

Previridicatumtoxin is a fungal metabolite that has been found in P. aethiopicum and has diverse biological activities.1,2 It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin . Previridicatumtoxin is active against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (IC50s = 4.4 and 4.8 μM, respectively), as well as C. albicans and S. cerevisiae (MIC = 32 μg/ml for both).2,1 It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC50s = 5.3, 4.1, and 6 μM, respectively).2

References

1.Chooi, Y.H., Wang, P., Fang, J., et al.Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferasesJ. Am. Chem. Soc.134(22)9428-9437(2012) 2.Shang, Z., Salim, A.A., Khalil, Z., et al.Viridicatumtoxins: Expanding on a rare tetracycline antibiotic scaffoldJ. Org. Chem.80(24)12501-12508(2015)

Properties of Previridicatumtoxin

storage temp.	Store at -20°C
solubility	Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
form	A solid

Safety information for Previridicatumtoxin

Computed Descriptors for Previridicatumtoxin

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