PREGNENOLONE SULFATE SODIUM SALT
Synonym(s):3β-Hydroxy-5-pregnen-20-one 3-sulfate;3-Hydroxypregn-5-en-20-one sulfate;5-Pregnen-3β-ol-20-one sulfate
- CAS NO.：1852-38-6
- Empirical Formula: C21H31NaO5S
- Molecular Weight: 418.52
- MDL number: MFCD00056177
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is PREGNENOLONE SULFATE SODIUM SALT?
Description
Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).
The Uses of PREGNENOLONE SULFATE SODIUM SALT
Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.
The Uses of PREGNENOLONE SULFATE SODIUM SALT
Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).
What are the applications of Application
Pregnenolone sulfate sodium salt is is a GABAA receptor antagonist
Biochem/physiol Actions
Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.
Storage
Store at +4°C
Properties of PREGNENOLONE SULFATE SODIUM SALT
| Melting point: | 192 °C(lit.) |
| storage temp. | Store at -20°C |
| solubility | methanol and water: 1.93 mg/mL |
| form | A crystalline solid |
| color | White to off-white |
Safety information for PREGNENOLONE SULFATE SODIUM SALT
Computed Descriptors for PREGNENOLONE SULFATE SODIUM SALT
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
![Pregnenolone-[20,21-13C2, 16,16-d2]](https://img.chemicalbook.in/)
![Pregnenolone-[20,21-13C2, 16,16-D2]](https://img.chemicalbook.in/CAS/20180629/GIF/CB12740996.gif)
![Pregnenolone-[20,21-13C2, 16,16-D2] sulfate sodium salt](https://img.chemicalbook.in/CAS/20180703/GIF/CB72740998.gif)
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