PREGNENOLONE SULFATE SODIUM SALT
Synonym(s):3β-Hydroxy-5-pregnen-20-one 3-sulfate;3-Hydroxypregn-5-en-20-one sulfate;5-Pregnen-3β-ol-20-one sulfate
- CAS NO.：1852-38-6
- Empirical Formula: C21H31NaO5S
- Molecular Weight: 418.52
- MDL number: MFCD00056177
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 19:39:08
What is PREGNENOLONE SULFATE SODIUM SALT?
Description
Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).
The Uses of PREGNENOLONE SULFATE SODIUM SALT
Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.
The Uses of PREGNENOLONE SULFATE SODIUM SALT
Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).
What are the applications of Application
Pregnenolone sulfate sodium salt is is a GABAA receptor antagonist
Biochem/physiol Actions
Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.
Storage
Store at +4°C
Properties of PREGNENOLONE SULFATE SODIUM SALT
| Melting point: | 192 °C(lit.) |
| storage temp. | Store at -20°C |
| solubility | methanol and water: 1.93 mg/mL |
| form | A crystalline solid |
| color | White to off-white |
Safety information for PREGNENOLONE SULFATE SODIUM SALT
Computed Descriptors for PREGNENOLONE SULFATE SODIUM SALT
New Products
3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Pentadecanoic acid Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 5-Bromo-2-Fluoropyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 4-Bromo-3-(ethoxymethyl)benzoic acid 2,4-Dichloro-5-methoxyaniline 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine N2-Isobutyryl-2'-O-methylguanosine 2-chloro-5-methylpyridin-4-amine 4-Bromobenzaldehyde 2-Chloro-6-nitro benzothiazole 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-one 5-Phenyl-[1,3,4]-thiadiazol-2-amineRelated products of tetrahydrofuran
![Pregnenolone-[20,21-13C2, 16,16-d2]](https://img.chemicalbook.in/)
![Pregnenolone-[20,21-13C2, 16,16-D2]](https://img.chemicalbook.in/CAS/20180629/GIF/CB12740996.gif)
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