Pregnenolone acetate

Synonym(s):3β-Acetoxy-5-pregnen-20-one;5-Pregnen-3β-ol-20-one acetate

CAS NO.：1778-02-5
Empirical Formula: C23H34O3
Molecular Weight: 358.51
MDL number: MFCD00003627
EINECS: 217-212-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 23:34:54

What is Pregnenolone acetate?

Chemical properties

white to light yellow crystalline powder or Crystallized (methanol).

The Uses of Pregnenolone acetate

Pregnenolone acetate is an intermediate in the synthesis of progesterone. It is uses as a glucocorticoid and as a skin-conditioning and skin anti-aging agent. It acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. It has also been shown to stimulate locomotor activity and neuronal function in rats.

Definition

Pregnenolone acetate is a steroid ester. It is a pregnenolone derivative, a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens.

Preparation

Pregnenolone acetate can be prepared by catalytic hydrogenation (16-position double bond) of 16-Dehydropregnenolone acetate.

Properties of Pregnenolone acetate

Melting point:	149-152 °C(lit.)
Boiling point:	430.93°C (rough estimate)
alpha	22 º (c=2, C2H5OH 23 ºC)
Density	1.0816 (rough estimate)
refractive index	1.4700 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form	Solid
color	White
optical activity	[α]20/D +19°, c = 1 in ethanol
Merck	14,7733
BRN	2062850
CAS DataBase Reference	1778-02-5(CAS DataBase Reference)
NIST Chemistry Reference	3Beta-acetoxypregn-5-en-20-one(1778-02-5)

Safety information for Pregnenolone acetate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.