Pregnenolone acetate
Synonym(s):3β-Acetoxy-5-pregnen-20-one;5-Pregnen-3β-ol-20-one acetate
- CAS NO.：1778-02-5
- Empirical Formula: C23H34O3
- Molecular Weight: 358.51
- MDL number: MFCD00003627
- EINECS: 217-212-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 09:27:42
What is Pregnenolone acetate?
Chemical properties
white to light yellow crystalline powder or Crystallized (methanol).
The Uses of Pregnenolone acetate
Pregnenolone acetate is an intermediate in the synthesis of progesterone. It is uses as a glucocorticoid and as a skin-conditioning and skin anti-aging agent. It acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. It has also been shown to stimulate locomotor activity and neuronal function in rats.
Definition
Pregnenolone acetate is a steroid ester. It is a pregnenolone derivative, a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens.
Preparation
Pregnenolone acetate can be prepared by catalytic hydrogenation (16-position double bond) of 16-Dehydropregnenolone acetate.
Properties of Pregnenolone acetate
| Melting point: | 149-152 °C(lit.) |
| Boiling point: | 430.93°C (rough estimate) |
| alpha | 22 º (c=2, C2H5OH 23 ºC) |
| Density | 1.0816 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White |
| optical activity | [α]20/D +19°, c = 1 in ethanol |
| Merck | 14,7733 |
| BRN | 2062850 |
| CAS DataBase Reference | 1778-02-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 3Beta-acetoxypregn-5-en-20-one(1778-02-5) |
Safety information for Pregnenolone acetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Pregnenolone acetate
| InChIKey | CRRKVZVYZQXICQ-RJJCNJEVSA-N |
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