Pranoprofen

Synonym(s):2-(5H-[1]-Benzopyrano[2,3-b]pyridin-7-yl)propionic acid;2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid;a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid

CAS NO.：52549-17-4
Empirical Formula: C15H13NO3
Molecular Weight: 255.27
MDL number: MFCD00866111
EINECS: 682-035-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-23 17:18:35

What is Pranoprofen?

Chemical properties

Off-White Solid

Originator

Niflan, Yoshitomi ,Japan ,1981

The Uses of Pranoprofen

Pranoprofen is an anti-inflammatory used in ophthalmology.

What are the applications of Application

Pranoprofen is a non-steroidal antiinflammatory

Definition

ChEBI: Pranoprofen is a pyridochromene.

Manufacturing Process

A mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C.

Therapeutic Function

Analgesic, Antiinflammatory

General Description

Pranoprofen is an arylalkanoic acid and a non-steroidal anti-inflammatory drug.

Biochem/physiol Actions

Pranoprofen is used in eyes to treat chronic allergic conjunctivitis. It is also used as an anti-inflammatory and analgesic drug after strabismus surgery.

Properties of Pranoprofen

Melting point:	182-183°
Boiling point:	398.5°C (rough estimate)
Density	1.1654 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	4.27±0.10(Predicted)
form	powder
color	white to beige
CAS DataBase Reference	52549-17-4(CAS DataBase Reference)