PPQ-102
Synonym(s):;CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
- CAS NO.：931706-15-9
- Empirical Formula: C26H22N4O3
- Molecular Weight: 438.48
- MDL number: MFCD14824240
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is PPQ-102?
What are the applications of Application
PPQ-102 is a cell-permeable inhibitor of CFTR- mediated chloride currents
General Description
A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.
Storage
Store at -20°C
Properties of PPQ-102
| Melting point: | >300℃ (ethanol ) |
| Boiling point: | 648.7±65.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | -20C |
| solubility | DMF: 0.2 mg/ml |
| form | White crystalline solid |
| pka | 1.00±0.40(Predicted) |
| color | Light yellow to yellow |
Safety information for PPQ-102
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PPQ-102
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