Potassium bis(trimethylsilyl)amide
Synonym(s):Hexamethyldisilazane potassium salt;Hexamethyldisilazane potassium salt solution;KHMDS;Potassium hexamethyldisilazide;Potassium hexamethyldisilazide solution
- CAS NO.:40949-94-8
- Empirical Formula: C6H18KNSi2
- Molecular Weight: 199.48
- MDL number: MFCD00010330
- EINECS: 424-100-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-08 17:36:13
What is Potassium bis(trimethylsilyl)amide?
Description
Potassium bis(trimethylsilyl)amide (KHMDS) is a sterically hindered strong base. It is commercially available as a solid and as a solution in a variety of solvents (ex. THF, 2Me-THF, toluene, and MTBE). Similar reagents include lithium bis(trimethylsilyl)amide (LiHMDS) and sodium bis(trimethylsilyl)amide (NaHMDS).
The Uses of Potassium bis(trimethylsilyl)amide
Potassium Bis(trimethylsilyl)amide (1M in THF) is used in the preparation of 5-azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions.
The Uses of Potassium bis(trimethylsilyl)amide
To a suspension of the SM (52 mg, 0.2 mmol) in THF (4 mL) was added NaH (60%, 16 mg, 0.4 mmol) at 0 C, and the mixture was stirred for 15 min. To this mixture was added MeI (42 mg, 0.3 mmol) in THF (1 mL) dropwise at 0 C. The reaction mixture was warmed to RT and stirred for 4 h. The mixture was quenched with aq Na2CO3, extracted with EtOAc (3x), and washed with brine. Column purification (20-100% EtOAc/heptane) provided the product as an off-white powder. [31 mg, 60%]
Properties of Potassium bis(trimethylsilyl)amide
Melting point: | 194-195°C |
Boiling point: | 111 °C |
Density | 0.877 g/mL at 25 °C |
Flash point: | 45 °F |
storage temp. | Refrigerator |
solubility | Miscible with terahydrofuran, ether, benzene and toluene. |
appearance | White crystals |
form | Liquid |
color | clear to slightly hazy yellow |
Water Solubility | Reacts with water. |
Sensitive | Moisture Sensitive |
Safety information for Potassium bis(trimethylsilyl)amide
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Potassium bis(trimethylsilyl)amide
Abamectin manufacturer
Sanpra Synthesis Private Limited
JLS Laboratories Pvt Limited
VASISTA LIFE SCIENCES PRIVATE LIMITED
Oceanic Pharmachem Pvt Ltd
JSK Chemicals
Organo Metallics
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