PNU-159682

CAS NO.：202350-68-3
Empirical Formula: C32H35NO13
Molecular Weight: 641.62
MDL number: MFCD12756329
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-20 17:00:22

What is PNU-159682?

Characteristics

PNU-159682, a metabolite of the anthracycline neomycin metabolite, is a DNA topoisomerase I (TopoI) inhibitor with excellent cytotoxicity. It is a more potent and tolerable ADC cytotoxin than doxorubicin in ADC synthesis.

The Uses of PNU-159682

PNU-159682 can be used in EDV nanocell technology to overcome drug resistance.

Properties of PNU-159682

Boiling point:	838.5±65.0 °C(Predicted)
Density	1.58±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	7.34±0.60(Predicted)
form	Solid
color	Reddish Brown to red

Safety information for PNU-159682

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for PNU-159682

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