Pimaric acid
- CAS NO.：127-27-5
- Empirical Formula: C20H30O2
- Molecular Weight: 302.45
- MDL number: MFCD28369457
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:52:52
What is Pimaric acid?
Description
Pimaric acid is a resin acid that has been found in A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml.
The Uses of Pimaric acid
A novel activators of large-conductance Ca2+-activated K+ channel α-subunit.
Definition
ChEBI: (+)-Pimaric acid is a diterpenoid.
Properties of Pimaric acid
| Melting point: | 217-219° |
| Boiling point: | bp18 282° |
| alpha | D18 +74.7° (c = 0.4 in chloroform); D20 +87.3° (in chloroform) |
| Density | 1.0434 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble,Water: soluble |
| form | Solid |
| pka | 4.68±0.60(Predicted) |
| color | White to off-white |
| EPA Substance Registry System | Pimaric acid (127-27-5) |
Safety information for Pimaric acid
Computed Descriptors for Pimaric acid
New Products
2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 2,4-Dihydroxybenzaldehyde Dipropyl disulfide Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Obidoxime hydrochloride API 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 2-Pentyn-1-oL 4-NitrobenzotrifluorideRelated products of tetrahydrofuran
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