PIMARIC ACID
- CAS NO.：127-27-5
- Empirical Formula: C20H30O2
- Molecular Weight: 302.45
- MDL number: MFCD28369457
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is PIMARIC ACID?
Description
Pimaric acid is a resin acid that has been found in A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml.
The Uses of PIMARIC ACID
A novel activators of large-conductance Ca2+-activated K+ channel α-subunit.
Definition
ChEBI: (+)-Pimaric acid is a diterpenoid.
Properties of PIMARIC ACID
| Melting point: | 217-219° |
| Boiling point: | bp18 282° |
| alpha | D18 +74.7° (c = 0.4 in chloroform); D20 +87.3° (in chloroform) |
| Density | 1.0434 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble,Water: soluble |
| form | Solid |
| pka | 4.68±0.60(Predicted) |
| color | White to off-white |
| EPA Substance Registry System | Pimaric acid (127-27-5) |
Safety information for PIMARIC ACID
Computed Descriptors for PIMARIC ACID
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