PHENMETRAZINE HYDROCHLORIDE CII (200 MG)

Chemical properties

White Solid

Originator

Preludin, Boehringer Ingelheim, US ,1956

The Uses of PHENMETRAZINE HYDROCHLORIDE CII (200 MG)

Anorexic. Controlled substance (stimulant).

Definition

ChEBI: Phenmetrazine hydrochloride is an organic molecular entity.

Manufacturing Process

10 grams of β-phenyl-α-methyl-β,β'-dihydroxy-diethylamine hydrochloride (produced by hydrogenation in the presence of palladium and charcoal of βphenyl-α-methyl-β-keto-β'-hydroxy-N-benzyl-diethylamine hydrochloride obtained from bromopropiophenone by reacting with benzyl-ethanolamine), are warmed with 10% hydrochloric acid for 6 hours on a water bath.After working up in the usual manner, the hydrochloride of the 2-phenyl-3methyl-morpholine crystallizes out from methanolic hydrochloric acid and acetone, MP = 182°C, according to US Patent 2,835,669.

brand name

Preludin (Boehringer Ingelheim).

Therapeutic Function

Antiobesity

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human reproductive effects. Human teratogenic effects by ingestion: developmental abnormalities of the respiratory and gastrointestinal systems, and effects on newborn including neonatal measures or effects. When heated to decomposition it emits very toxic fumes of NOx and HCl.