PHALLACIDIN

Synonym(s):Cyclo(Ala-2-Mercapto-Trp-4,5-Dihydroxy-Leu-Val-erythro-3-Hydroxy-D-Asp-Cys-cis-4-Hydroxy-Pro)

CAS NO.：26645-35-2
Empirical Formula: C37H50N8O13S
Molecular Weight: 846.9
MDL number: MFCD00063359
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:22:44

What is PHALLACIDIN?

Description

Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. It binds filamentous actin (F-actin) like phalloidin , but contains a carboxyl group for coupling reactions.

The Uses of PHALLACIDIN

Toxin Phallacidin is a weak fluorescent bicyclic peptide probe in aquous solution, Which is isolated from Amanita phalloides mushroom and could be used for blocking F-actin staining by labeled phallotoxins, which promotes actin polymerization.

The Uses of PHALLACIDIN

Phallacidin is a natural mycotoxin first isolated from the death cap mushroom. It binds filamentous actin like phalloidin.

What are the applications of Application

Phallacidin is an F-actin stabilizing toxin useful for conjugation to fluorescent molecules to actin filaments

Definition

ChEBI: A homodetic bicyclic heptapeptide having a sulfide bridge.

Biochem/physiol Actions

Phallacidin, which is a bicyclic toxin from the Amanita phalloides mushroom, has been shown to inhibit F-actin degradation by proteolytic enzymes including trypsin and α-chymotrypsin.

Enzyme inhibitor

This cyclic heptapeptide toxin (FWfree-acid = 846.92 g/mol; CAS 26645-35-2) from the poisonous green fungus Amanita phalloides stabilizes actin filaments and inhibits actin filament depolymerization. NBD phallacidin is a high-affinity, filamentous actin probe consisting of rabbit actin that is conjugated by reacting its thiol group with 4-chloro-7- nitrobenzofurazan, a yellow-green fluorescent dye. NBD phallacidin (Excitation at 465 nm; Emission at 536 nm) selectively stains F-actin un a manner that is superior to antibody staining, preferably in fixed and permeabilized samples. See Phalloidin

Properties of PHALLACIDIN

Density	1.1678 (rough estimate)
refractive index	1.7400 (estimate)
solubility	DMF: Soluble; DMSO: Soluble; Methanol: Soluble; Water: Soluble
form	White to off-white powder.
color	White to off-white

Safety information for PHALLACIDIN

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection.