Pentafluorobenzoyl chloride
Synonym(s):Pentafluorobenzoic acid chloride;Perfluorobenzoyl chloride
- CAS NO.:2251-50-5
- Empirical Formula: C7ClF5O
- Molecular Weight: 230.52
- MDL number: MFCD00000657
- EINECS: 218-842-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:23:24
What is Pentafluorobenzoyl chloride?
Description
Pentafluorobenzoyl chloride is the acid chloride of pentafluorobenzoic acid. It is a sensitive derivatising reagent for the analysis of amines, amides and phenols by electron capture gas chromatography. It has a role as a chromatographic reagent. It is an acyl chloride and a perfluorinated compound. It derives from a pentafluorobenzoic acid.
2,3,4,5,6-Pentafluorobenzoyl chloride was used for derivatization of 5-androstenediol, testosterone, estradiol , dihydrotestosterone and estrone in a study to determine their serum levels. 2,3,4,5,6-Pentafluorobenzoyl chloride was used to derivatize dimethylamine(DMA) in study to develop a rapid and accurate GC–MS method for determination of DMA in human urine. 2,3,4,5,6-Pentafluorobenzoyl chloride was used in a study to detect the presence of Enterobacter cloacae in cultures of Leuconostoc mesenteroide by gas chromatography/mass spectrometry.
Chemical properties
clear colorless to light yellow liquid
The Uses of Pentafluorobenzoyl chloride
Pentafluorobenzoyl Chloride is a useful analytical reagent in the derivatization amphetamines as well as other primary amines.
The Uses of Pentafluorobenzoyl chloride
Pentafluorobenzoyl chloride can be used for the derivatization of a variety of analytes including biological amines. There is an extensive use for the derivatization of lipids.
The Uses of Pentafluorobenzoyl chloride
A reagent used for deriving primary amines. 2,3,4,5,6-Pentafluorobenzoyl chloride was used for derivatization of 5-androstenediol, testosterone, estradiol , dihydrotestosterone and estrone in a study to determine their serum levels. 2,3,4,5,6-Pentafluorobenzoyl chloride was used to derivative dimethylamine(DMA) in study to develop a rapid and accurate GC-MS method for determination of DMA in human urine. It was used in a study to detect the presence of Enterobacter cloacae in cultures of Leuconostoc mesenteroide by gas chromatography/mass spectrometry.
What are the applications of Application
2,3,4,5,6-Pentafluorobenzoyl chloride is a reagent used for deriving primary amines
Definition
ChEBI: The acid chloride of pentafluorobenzoic acid. It is a sensitive derivatising reagent for the analysis of amines, amides and phenols by electron capture gas chromatography.
Properties of Pentafluorobenzoyl chloride
| Boiling point: | 158-159 °C(lit.) |
| Density | 1.601 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | None |
| storage temp. | Store below +30°C. |
| solubility | soluble in Chloroform |
| form | Liquid |
| Specific Gravity | 1.601 |
| color | Clear colorless to light yellow |
| Water Solubility | decomposes |
| Sensitive | Lachrymatory |
| BRN | 2054397 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 2251-50-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Pentafluorobenzoyl chloride(2251-50-5) |
Safety information for Pentafluorobenzoyl chloride
| Signal word | Danger |
| Pictogram(s) |
![]() Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Pentafluorobenzoyl chloride
| InChIKey | MYHOHFDYWMPGJY-UHFFFAOYSA-N |
New Products
Paroxetine Impurity G/Paroxetine Related Compound E 1-Aminocyclopentane carbonitrile (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine(RM for Indian lab) Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate (R)-1-Benzyl-3-pyrrolidinecarbonitrile Betahistine EP Impurity C Cyclobenzaprine N-oxide/Citalopram Related Compound E Chlorthalidone Impurity I Carbamazepine EP Impurity G Sumatriptan Succinate USP Related Compound C 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 4-Bromo Benzylcyanide 3-Hydroxypropionitrile valeronitrile 3,4 Dimethoxy Benzylcyanide 3-chlorobenzyl cyanide 2-Chloro BenzylcyanideRelated products of tetrahydrofuran








You may like
-
Pentafluorobenzoyl chloride 95% CAS 2251-50-5View Details
2251-50-5 -
Pentafluorobenzoyl Chloride CAS 2251-50-5View Details
2251-50-5 -
2,3,4,5,6-Pentafluorobenzoyl chloride CAS 2251-50-5View Details
2251-50-5 -
2847776-12-7 Sumatriptan Succinate USP Related Compound C NLT 95%View Details
2847776-12-7 -
1012886-75-7(HCl Salt)/69675-10-1(Freebase) Paroxetine Impurity G/Paroxetine Related Compound E NLT 95%View Details
1012886-75-7(HCl Salt)/69675-10-1(Freebase) -
Bromoacetaldehyde Dimethyl Acetal (stabilized with K2CO3)View Details
7252-83-7 -
157528-56-8 (R)-1-Benzyl-3-pyrrolidinecarbonitrile 98+View Details
157528-56-8 -
157528-56-8 (R)-1-Benzyl-3-pyrrolidinecarbonitrile 98+View Details
157528-56-8

