PANCREATIC POLYPEPTIDE, HUMAN
- CAS NO.：75976-10-2
- Empirical Formula: C185H287N53O54S2
- Molecular Weight: 4181.71098
- MDL number: MFCD00081812
- Update Date: 2025-06-18 16:39:34
What is PANCREATIC POLYPEPTIDE, HUMAN?
Description
Pancreatic polypeptide is an agonist of neuropeptide Y (NPY) receptors that reduces forskolin-induced cAMP accumulation in L-M(TK-) cells recombinantly expressing human and rat Y4 receptors (EC50s = 87.1 and 36.3 pM, respectively). It binds to Y1 and Y5 receptors with Ki values of 19 and 3.9 nM, respectively, for human and 50 and 2.4 nM, respectively, for rhesus monkey receptors. Pancreatic polypeptide also binds to rabbit Y1, Y2, Y4, and Y5 receptors (Kis = 0.39, 0.087, 0.79, and 0.24 nM, respectively). It induces contractile responses in isolated rat colon with EC50 values of 1.6 and 0.7 nM for ascending and descending colon segments, respectively. In vivo, pancreatic polypeptide (0.7-7 nmol, i.c.v.) increases food intake in rats.
Clinical Use
PP secretion from the pancreas in response to vagal nerve stimulation has been used as a diagnostic test of vagal nerve function.
Storage
Store at -20°C
Properties of PANCREATIC POLYPEPTIDE, HUMAN
| storage temp. | -15°C |
| solubility | Water: 1 mg/ml |
| form | Powder |
| color | White to off-white |
| Water Solubility | Soluble to 0.70 mg/ml in water |
Safety information for PANCREATIC POLYPEPTIDE, HUMAN
Computed Descriptors for PANCREATIC POLYPEPTIDE, HUMAN
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