Pamoic acid disodium salt

Synonym(s):4,4′-Methylenebis(3-hydroxy-2-naphthoic acid);Embonic acid;Sodium pamoate

CAS NO.：6640-22-8
Empirical Formula: C23H17NaO6
Molecular Weight: 412.37
MDL number: MFCD00036183
EINECS: 229-653-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:12:44

What is Pamoic acid disodium salt?

Chemical properties

pale yellow to yellow powder

The Uses of Pamoic acid disodium salt

Pamoic acid disodium salt, a supposedly inactive component in many formulations of drugs used to modulate release, is a potent agonist of the orphan receptor GPR35. GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR), strongly expressed in the lower intestine and colon, dorsal root ganglia, as well as a variety of immune cells including monocytes and dendritic cells. Targeting GPR35 provides potential therapeutic opportunities in a range of conditions, such as inflammation, pain and cancer.

What are the applications of Application

Pamoic acid disodium salt is an agonist that induces GPR35 internalization and activates ERK1/2

Flammability and Explosibility

Not classified

Biological Activity

Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.

Properties of Pamoic acid disodium salt

Melting point:	300 °C
Density	1.55[at 20℃]
vapor pressure	0.001Pa at 25℃
storage temp.	Desiccate at RT
solubility	insoluble in EtOH; ≥18 mg/mL in H2O; ≥28.6 mg/mL in DMSO
form	solid
color	Pale yellow
Water Solubility	43g/L at 20℃
CAS DataBase Reference	6640-22-8(CAS DataBase Reference)
EPA Substance Registry System	2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, disodium salt (6640-22-8)

Safety information for Pamoic acid disodium salt

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.