Pamoic acid disodium salt
Synonym(s):4,4′-Methylenebis(3-hydroxy-2-naphthoic acid);Embonic acid;Sodium pamoate
- CAS NO.：6640-22-8
- Empirical Formula: C23H17NaO6
- Molecular Weight: 412.37
- MDL number: MFCD00036183
- EINECS: 229-653-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is Pamoic acid disodium salt?
Chemical properties
pale yellow to yellow powder
The Uses of Pamoic acid disodium salt
Pamoic acid disodium salt, a supposedly inactive component in many formulations of drugs used to modulate release, is a potent agonist of the orphan receptor GPR35. GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR), strongly expressed in the lower intestine and colon, dorsal root ganglia, as well as a variety of immune cells including monocytes and dendritic cells. Targeting GPR35 provides potential therapeutic opportunities in a range of conditions, such as inflammation, pain and cancer.
What are the applications of Application
Pamoic acid disodium salt is an agonist that induces GPR35 internalization and activates ERK1/2
Flammability and Explosibility
Not classified
Biological Activity
Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.
Properties of Pamoic acid disodium salt
| Melting point: | 300 °C |
| Density | 1.55[at 20℃] |
| vapor pressure | 0.001Pa at 25℃ |
| storage temp. | Desiccate at RT |
| solubility | insoluble in EtOH; ≥18 mg/mL in H2O; ≥28.6 mg/mL in DMSO |
| form | solid |
| color | Pale yellow |
| Water Solubility | 43g/L at 20℃ |
| CAS DataBase Reference | 6640-22-8(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, disodium salt (6640-22-8) |
Safety information for Pamoic acid disodium salt
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Pamoic acid disodium salt
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