P-TOLUENESULFONYL FLUORIDE
- CAS NO.：455-16-3
- Empirical Formula: C7H7FO2S
- Molecular Weight: 174.19
- MDL number: MFCD00007421
- EINECS: 207-238-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-16 09:55:32
What is P-TOLUENESULFONYL FLUORIDE?
Chemical properties
White to beige fused mass
The Uses of P-TOLUENESULFONYL FLUORIDE
p-Toluenesulfonyl fluoride is used for sulfonylation of organometallic reagents as a simple, one-step synthesis of sulfones. It is useful in the treatment of Alzheimer?s disease. It is used to study the DNS polymerase from spinach leaf extracts. It was used in isolation and separation of Pseudomonas aeruginosa membranes by density sucrose gradient centrifugation.
The Uses of P-TOLUENESULFONYL FLUORIDE
Protease inhibitor.
General Description
p-Toluenesulfonyl fluoride is a peroxygen bleach activator and is also useful in the treatment of Alzheimer′s disease.
Properties of P-TOLUENESULFONYL FLUORIDE
| Melting point: | 41-42 °C(lit.) |
| Boiling point: | 112 °C16 mm Hg(lit.) |
| Density | 1.2768 (estimate) |
| Flash point: | 222 °F |
| Water Solubility | Hydrolyzes in water. |
| Sensitive | Moisture Sensitive |
| BRN | 2208423 |
| Exposure limits | ACGIH: TWA 2.5 mg/m3 NIOSH: IDLH 250 mg/m3 |
| CAS DataBase Reference | 455-16-3(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenesulfonyl fluoride, 4-methyl- (455-16-3) |
Safety information for P-TOLUENESULFONYL FLUORIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for P-TOLUENESULFONYL FLUORIDE
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![8-CYCLOPENTYL-N3-[3-(4-(FLUOROSULFONYL)BENZOYLOXY)PROPYL]-N1-PROPYLXANTHINE](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB8429364.gif)
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