Octanoic acid, 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl][3-[[2-(methylamino)-3,4-dioxo-1-cyclobuten-1-yl]amino]propyl]amino]-, 1-octylnonyl ester

CAS NO.：2244716-55-8
Empirical Formula: C52H97N3O6
Molecular Weight: 860.34
Update Date: 2025-04-17 18:22:24

What is Octanoic acid, 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl][3-[[2-(methylamino)-3,4-dioxo-1-cyclobuten-1-yl]amino]propyl]amino]-, 1-octylnonyl ester?

Biological Activity

Lipid 29 is an ionizable amino lipid (pKa = 6.91) that has been used in combination with other lipids in the formation of lipid nanoparticles.1 Administration of human erythropoietin (EPO) mRNA in lipid 29-containing lipid nanoparticles increases serum EPO levels in mice.

References

1.Cornebise, M., Narayanan, E., Xia, Y., et al.Discovery of a novel amino lipid that improves lipid nanoparticle performance through specific interactions with mRNAAdv. Funct. Mater.32(8)2106727(2106721-2106712)(2021)

Properties of Octanoic acid, 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl][3-[[2-(methylamino)-3,4-dioxo-1-cyclobuten-1-yl]amino]propyl]amino]-, 1-octylnonyl ester

Boiling point:	823.8±75.0 °C(Predicted)
Density	0.99±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Ethanol: 25 mg/ml
pka	9.49±0.50(Predicted)
form	Oil
color	Colorless to light yellow

Safety information for Octanoic acid, 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl][3-[[2-(methylamino)-3,4-dioxo-1-cyclobuten-1-yl]amino]propyl]amino]-, 1-octylnonyl ester

Computed Descriptors for Octanoic acid, 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl][3-[[2-(methylamino)-3,4-dioxo-1-cyclobuten-1-yl]amino]propyl]amino]-, 1-octylnonyl ester

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