OBAA

CAS NO.：221632-26-4
Empirical Formula: C28H44O3
Molecular Weight: 428.65
Update Date: 2026-03-18 11:52:23

What is OBAA?

Definition

ChEBI: 4-(4-octadecylphenyl)-4-oxo-2-butenoic acid is a carbonyl compound.

Enzyme inhibitor

This potent PLA inhibitor (FW = 428.65 g/mol; CAS 221632-26-4; Soluble to 10 mM in DMSO with gentle warming), also named 4-(4- octadecylphenyl)-4-oxobutenoic acid, targets phospholipase A2 (IC50 = 70 nM). OBAA is a mechanism-based inhibitor, showing a typical timedependence as well as a molar inactivation ratio of twenty OBAA hydrolyzed per molecule of irreversibly inactivated enzyme. Doublereciprocal replots of the apparent inactivation constants versus OBAA concentration gave a (pseudo) first-order rate constant of inactivation of 2.3 min–1 and a dissociation constant of 6 x 10–6 M–1 for the enzyme-inhibitor intermediate. OBAA reduces bronchospasm in guinea pigs in vivo.

Properties of OBAA

Boiling point:	558.6±50.0 °C(Predicted)
Density	0.976±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble to 10 mM in DMSO with gentle warming
form	Powder
pka	3.20±0.10(Predicted)

Safety information for OBAA

Computed Descriptors for OBAA

New Products

2-(2-aminoethyl) benzenesulfonamide Gemcitabine 3-benzoate impurity Dihydroxyphenylacetone Ornidazole EP impurity D Acetyl amino diol impurity Valsartan Benzyl Ester Impurity B N,N'-Dicyclohexylcarbodiimide 3-Bromo-2-Methyl-5-Nitropyridine 5-Bromo-3-Methyl-2-Pyridinecarboxylic acid 2-Amino-4-Methylpyridine 4-Aminopyridine 4-dimethylaminopyridine