Nsc66811

CAS NO.：6964-62-1
Empirical Formula: C23H20N2O
Molecular Weight: 340.42
MDL number: MFCD08823776
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is Nsc66811?

Description

NSC 66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.

The Uses of Nsc66811

NSC 66811 is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. NSC 66811 activates p53 in colon cancer cells.

References

1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759

Properties of Nsc66811

Melting point:	143.0 to 147.0 °C
Boiling point:	529.5±45.0 °C(Predicted)
Density	1.235±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Soluble in DMSO (up to 25 mg/ml).
form	solid
pka	4.42±0.50(Predicted)
color	White
λmax	250nm(EtOH)(lit.)
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety information for Nsc66811

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.