NPS 2143

Synonym(s):2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1);NPS-2143 hydrochloride;SB-262470-A hydrochloride

CAS NO.：284035-33-2
Empirical Formula: C24H25ClN2O2
Molecular Weight: 408.92
MDL number: MFCD04113010
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-07 19:09:50

What is NPS 2143?

The Uses of NPS 2143

NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.

Biological Activity

nps-2143 is a novel and selective antagonist of casr (ca2+-sensing receptor) with the ec50 value of 4.27mm for [ca2+]o [1].calcilytics nps-2143 has been reported to diminish the sensitivity of the casr for [ca2+]o, resulting in an attenuated signal transduction in vitro and increased secretion of pth in vivo. in addition, the ec50 values of nps-2143 are 4.27, 1.56, 1.61, 2.46, 2.07 and 3.15mm for the wild-type casr, mutant casr (t151r, p221l, e767q, g830s, and a844t), respectively. apart from these, in hek 293t cells expressing casr, nps-2143 has been revealed to inhibit the [ca2+]o-induced cytosolic calcium signal in a concentration-dependent manner [1]..

References

[1] letz s1, rus r, haag c, dörr hg, schnabel d, möhlig m, schulze e, frank-raue k, raue f, mayr b, schöfl c. novel activating mutations of the calcium-sensing receptor: the calcilytic nps-2143 mitigates excessive signal transduction of mutant receptors. j clin endocrinol metab. 2010 oct;95(10):e229-33.

Properties of NPS 2143

Boiling point:	608.4±55.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	Desiccate at RT
solubility	≥40.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH
form	Powder
pka	13.67±0.20(Predicted)
color	White to off-white

Safety information for NPS 2143

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…