NOSCAPINE HYDROCHLORIDE
- CAS NO.：912-60-7
- Empirical Formula: C22H24ClNO7
- Molecular Weight: 449.88
- MDL number: MFCD00082546
- EINECS: 213-014-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:21:00
What is NOSCAPINE HYDROCHLORIDE?
Chemical properties
White or almost white, crystalline powder or colourless crystals, hygroscopic.
The Uses of NOSCAPINE HYDROCHLORIDE
Noscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.
The Uses of NOSCAPINE HYDROCHLORIDE
topical fluoroquinolone antibiotic for acne
The Uses of NOSCAPINE HYDROCHLORIDE
Anti-Tussive
What are the applications of Application
Noscapine hydrochloride is a bradykinin B and tubulin inhibitor
Biological Activity
Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.
Safety Profile
Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.
Properties of NOSCAPINE HYDROCHLORIDE
| Melting point: | 221-223 °C(lit.) |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand. |
| form | neat |
| color | Crystals |
| Merck | 13,6752 |
| EPA Substance Registry System | 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7) |
Safety information for NOSCAPINE HYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H336:Specific target organ toxicity,single exposure; Narcotic effects |
Computed Descriptors for NOSCAPINE HYDROCHLORIDE
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![(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol](https://img.chemicalbook.in/CAS/GIF/485-19-8.gif)
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