NORVERAPAMIL HYDROCHLORIDE
Synonym(s):N-Nor-(±)-verapamil hydrochloride
- CAS NO.：67812-42-4
- Empirical Formula: C26H37ClN2O4
- Molecular Weight: 477.04
- MDL number: MFCD00078605
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-03 18:03:33
What is NORVERAPAMIL HYDROCHLORIDE?
Chemical properties
Off-White Crystalline Solid
The Uses of NORVERAPAMIL HYDROCHLORIDE
A metabolite of Verapamil
The Uses of NORVERAPAMIL HYDROCHLORIDE
Nor Verapamil Hydrochloride (Verapamil EP Impurity J HCl) is a metabolite of Verapamil.
What are the applications of Application
Norverapamil, Hydrochloride is a calcium channel protein inhibitor
General Description
Norverapamil is a primary urinary metabolite of verapamil, a calcium channel blocker used in the treatment of hypertension, angina pectoris, and cardiac arrhythmia. Verapamil is also an effective preventive medication for migraines. This Certified Reference Material is applicable for use as starting material in calibrators or controls for verapamil testing methods by LC-MS/MS or GC-MS.
Biochem/physiol Actions
Norverapamil is an N-demethylated metabolite of verapamil. It has significantly less calcium channel blocking ability and exhibit therapeutic activity.
Properties of NORVERAPAMIL HYDROCHLORIDE
| Melting point: | softens at 50°C, 155-160°C dec. |
| Flash point: | 9℃ |
| storage temp. | desiccated |
| solubility | H2O: >10 mg/mL |
| form | solid |
| color | white |
| Stability: | Hygroscopic |
| EPA Substance Registry System | Benzeneacetonitrile, .alpha.-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)-, hydrochloride (1:1) (67812-42-4) |
Safety information for NORVERAPAMIL HYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NORVERAPAMIL HYDROCHLORIDE
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