Norfloxacin hydrochloride

CAS NO.：104142-93-0
Empirical Formula: C16H18FN3O3.HCl
Molecular Weight: 355.79
MDL number: MFCD01075766
EINECS: 213-535-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:41:06

What is Norfloxacin hydrochloride?

Biological Activity

norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacteria, which functions by inhibiting dna gyrase.

in vitro

Norfloxacin hydrochloride (MK-0366 hydrochloride) is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance.

Properties of Norfloxacin hydrochloride

Melting point:	220 °C
solubility	insoluble in EtOH; ≥27.3 mg/mL in H2O; ≥5.05 mg/mL in DMSO with gentle warming
InChI	InChI=1S/C16H18FN3O3.ClH/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;/h7-9,18H,2-6H2,1H3,(H,22,23);1H

Safety information for Norfloxacin hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H320:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.