Norfloxacin hydrochloride
- CAS NO.：104142-93-0
- Empirical Formula: C16H18FN3O3.HCl
- Molecular Weight: 355.79
- MDL number: MFCD01075766
- EINECS: 213-535-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:35
What is Norfloxacin hydrochloride?
Biological Activity
norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacteria, which functions by inhibiting dna gyrase.
in vitro
Norfloxacin hydrochloride (MK-0366 hydrochloride) is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance.
Properties of Norfloxacin hydrochloride
| Melting point: | 220 °C |
| solubility | insoluble in EtOH; ≥27.3 mg/mL in H2O; ≥5.05 mg/mL in DMSO with gentle warming |
| InChI | InChI=1S/C16H18FN3O3.ClH/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;/h7-9,18H,2-6H2,1H3,(H,22,23);1H |
Safety information for Norfloxacin hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H320:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Norfloxacin hydrochloride
| InChIKey | JJWDELPVPRCLQN-UHFFFAOYSA-N |
| SMILES | C12C=C(C(F)=CC=1C(=O)C(C(=O)O)=CN2CC)N1CCNCC1.Cl |
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