Norfloxacin
Synonym(s):1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid;1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid;Norfloxacin
- CAS NO.:70458-96-7
- Empirical Formula: C16H18FN3O3
- Molecular Weight: 319.33
- MDL number: MFCD00079532
- EINECS: 274-614-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-29 09:04:03
What is Norfloxacin?
Absorption
Rapid
Description
Norfloxacin is the first of the third generation nalidixic acid analogs to reach the marketplace. It exhibits potent in vitro and in vivo activity against Pseudomonas, enteric gram-negative rods and gram-positive cocci. Norfloxacin is orally effective in the treatment of urinary tract infections, including those due to organisms refractory to many other agents.
The Uses of Norfloxacin
It finds it application as a fluorinated quinolone antibacterial. It is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.
What are the applications of Application
Norfloxacin is a fluorinated quinolone antibacterial agent
Indications
For the treatment of urinary tract infection
Background
A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Pharmacokinetics
Norfloxacin is a quinolone/fluoroquinolone antibiotic. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
Metabolism
Via liver and kidney
Properties of Norfloxacin
Melting point: | 220°C |
Boiling point: | 555.8±50.0 °C(Predicted) |
Density | 1.2504 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Very slightly soluble in water, slightly soluble in acetone and in ethanol (96 per cent). |
form | Crystalline Powder |
color | White to yellow |
Water Solubility | Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water |
Safety information for Norfloxacin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Norfloxacin
InChIKey | OGJPXUAPXNRGGI-UHFFFAOYSA-N |
Abamectin manufacturer
Ralington Pharma
Aarti Drugs Ltd (part of Aarti Group of Industries)
Sreepathi Pharmaceuticals Limited
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