norfenefrine
- CAS NO.：536-21-0
- Empirical Formula: C8H11NO2
- Molecular Weight: 153.18
- MDL number: MFCD00215852
- EINECS: 2086268
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is norfenefrine?
Originator
Zordel,Grelan,Japan,1970
Definition
ChEBI: Norfenefrine is a member of phenols.
Manufacturing Process
100 parts of the hydrochloride of meta-hydroxy-ω-aminoacetophenone of melting point 220°C to 222°C (obtainable by brominating metaacetoxyacetophenone, causing the bromoketone to react with sodium iodide, adding hexamethylenetetramine to the iodide in an indifferent solvent and scission of the addition product in acid solution) are shaken in aqueous solution with hydrogen in presence of 2 parts of palladium catalyst until 2 atomic proportions of hydrogen have been absorbed. The catalyst is now filtered and the filtrate evaporated in a vacuum; and the crystalline and completely dry residue is dissolved in absolute alcohol and a precipitate is produced by adding dry ether. The hydrochloride of metahydroxyphenylethanolamine thus obtained forms white crystals of melting point 159°C to 160°C.
Therapeutic Function
Adrenergic
Properties of norfenefrine
| Melting point: | 75-77 °C |
| Boiling point: | 276.1°C (rough estimate) |
| Density | 1.1577 (rough estimate) |
| refractive index | 1.5010 (estimate) |
| pka | pKa 8.67(H2O,t undefined,I undefined) (Uncertain) |
Safety information for norfenefrine
Computed Descriptors for norfenefrine
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