Nomegestrol

CAS NO.：58691-88-6
Empirical Formula: C21H28O3
Molecular Weight: 328.45
MDL number: MFCD00867856
EINECS: 200-258-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-03 18:03:33

What is Nomegestrol?

Description

Nomegestrol acetate is the 19-nor derivative of megestrol acetate, useful in the treatment of gynecological conditions associated with luteal deficiency.

Description

Nomegestrol is a derivative of 19-norprogesterone. It increases nuclear levels of the progesterone receptor in rat uterus when administered at a dose of 1 mg/animal.

Originator

Theramex (Monaco)

The Uses of Nomegestrol

A progestogen, derivatives of which are used in contraceptives and hormone therapies.

The Uses of Nomegestrol

Progetin used in implantable hormone replacement therapies.

Background

Nomegestrol is an ingredient in the EMA-authorised product Zoely.

What are the applications of Application

Nomegestrol is a progestogen, derivatives are used in contraceptives and hormone therapies

Definition

ChEBI: Nomegestrol is a corticosteroid hormone.

brand name

LUTENYL

General Description

Nomegestrol acetate, 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione acetate,is being investigated as the progestin component of anew oral contraceptive, in combination with the estrogenestradiol. This new combination, NOMAC/E2, is in phaseIII trials and would be the first oral contraceptive to utilizeestradiol itself as the estrogenic component. Structurally,NOMAC is considered a nor-progesterone derivative thatlacks the C19 methyl group in megestrol acetate.

Metabolism

Not Available

Properties of Nomegestrol

Boiling point:	502.6±50.0 °C(Predicted)
Density	1.17±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform: soluble,DMSO: slightly soluble,Methanol: slightly soluble
pka	12.99±0.60(Predicted)
form	A solid