Nomegestrol

Description

Nomegestrol acetate is the 19-nor derivative of megestrol acetate, useful in the treatment of gynecological conditions associated with luteal deficiency.

Description

Nomegestrol is a derivative of 19-norprogesterone. It increases nuclear levels of the progesterone receptor in rat uterus when administered at a dose of 1 mg/animal.

Originator

Theramex (Monaco)

The Uses of Nomegestrol

A progestogen, derivatives of which are used in contraceptives and hormone therapies.

The Uses of Nomegestrol

Progetin used in implantable hormone replacement therapies.

Background

Nomegestrol is an ingredient in the EMA-authorised product Zoely.

What are the applications of Application

Nomegestrol is a progestogen, derivatives are used in contraceptives and hormone therapies

Definition

ChEBI: Nomegestrol is a corticosteroid hormone.

brand name

LUTENYL

General Description

Nomegestrol acetate, 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione acetate,is being investigated as the progestin component of anew oral contraceptive, in combination with the estrogenestradiol. This new combination, NOMAC/E2, is in phaseIII trials and would be the first oral contraceptive to utilizeestradiol itself as the estrogenic component. Structurally,NOMAC is considered a nor-progesterone derivative thatlacks the C19 methyl group in megestrol acetate.

Metabolism

Not Available