N,N-DIETHYLNICOTINAMIDE
Synonym(s):‘Nikethamide’;N,N-Diethylnicotinamide;DENC;Nicotinic acid diethylamide
- CAS NO.：59-26-7
- Empirical Formula: C10H14N2O
- Molecular Weight: 178.23
- MDL number: MFCD00006386
- EINECS: 200-418-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:18:46
What is N,N-DIETHYLNICOTINAMIDE?
Description
A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.
Chemical properties
clear colorless to yellow liquid
The Uses of N,N-DIETHYLNICOTINAMIDE
analeptic
The Uses of N,N-DIETHYLNICOTINAMIDE
N,N-Diethylnicotinamide (DENC) is commonly used as a ligand to prepare tetranuclear copper complexes.
Definition
ChEBI: Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.
What are the applications of Application
N,N-Diethylnicotinamide (DENA) is one of the central respiratory stimulants and is used in the study of respiratory failure. DENA is also an excellent hydrophilic agent for paclitaxel (PTX) and improves the water solubility of PTX.
General Description
Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.
Air & Water Reactions
Water soluble.
Reactivity Profile
N,N-DIETHYLNICOTINAMIDE is incompatible with sodium carbonate solutions which cause precipitation. .
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N-DIETHYLNICOTINAMIDE emits toxic fumes.
Fire Hazard
N,N-DIETHYLNICOTINAMIDE is combustible.
Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
References
Yunusov, Akramov, Yunusov, Dokl. Akad. Nauk. USSR, 162,607 (1965)
Yunusov, Akramov, Yunusov, Khim. Prir. Soedin., 2, 340 (1966)
Ibragimova, Yunusov, Yunusov, ibid, 6,438 (1970)
Yunusov, et al., ibid, 7, 380 (1971)
Properties of N,N-DIETHYLNICOTINAMIDE
| Melting point: | 23 °C (lit.) |
| Boiling point: | 296-300 °C (lit.) |
| Density | 1.06 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | pKa 3.46(H2O,t =20) (Uncertain) |
| form | Liquid |
| color | Clear colorless to yellow |
| Merck | 14,6543 |
| BRN | 5743 |
| InChI | InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3 |
| CAS DataBase Reference | 59-26-7(CAS DataBase Reference) |
| EPA Substance Registry System | Nikethamide (59-26-7) |
Safety information for N,N-DIETHYLNICOTINAMIDE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for N,N-DIETHYLNICOTINAMIDE
| InChIKey | NCYVXEGFNDZQCU-UHFFFAOYSA-N |
| SMILES | C1=NC=CC=C1C(N(CC)CC)=O |
N,N-DIETHYLNICOTINAMIDE manufacturer
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