N,N-Diethylacetoacetamide

CAS NO.：2235-46-3
Empirical Formula: C8H15NO2
Molecular Weight: 157.21
MDL number: MFCD00026728
EINECS: 218-792-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 01:12:58

What is N,N-Diethylacetoacetamide?

Chemical properties

Clear yellow liquid

The Uses of N,N-Diethylacetoacetamide

N,N-Diethylacetoacetamide is used as intermediate for the manufacture of insecticides, e.g. phosphamidon Product Data Sheet

The Uses of N,N-Diethylacetoacetamide

N,N-Diethylacetoacetamide is an intermediate in the synthesis of Phosphamidon (E/Z mixture) (P353730), an organophosphate insecticide that acts as a cholinesterase inhibitor.

The Uses of N,N-Diethylacetoacetamide

N,N-Diethylacetoacetamide is a β-dicarbonyl compound that ?can be used to synthesize potent calcium channel blockers such as 2,6,6-trimethyl-3-diethylaminocarbonyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives and N,N-diethyl-2,6,6-trimethyl-4-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide. It can also undergo Michael addition in the presence of bis(2,4-pentanedionato)nickel(II) catalyst.

Flammability and Explosibility

Flammable

Properties of N,N-Diethylacetoacetamide

Melting point:	-73 °C
Boiling point:	76 °C(lit.)
Density	0.994 g/mL at 20 °C (lit.)
vapor pressure	1.387Pa at 25℃
refractive index	n20/D 1.471
Flash point:	94 °C
storage temp.	Inert atmosphere,Room Temperature
form	clear liquid
pka	12.97±0.46(Predicted)
color	yellow
PH	5-7 (10g/l, H2O, 20℃)
explosive limit	1%(V)
Water Solubility	10g/L at 26℃
BRN	636486
CAS DataBase Reference	2235-46-3(CAS DataBase Reference)
NIST Chemistry Reference	Butanamide, N,N-diethyl-3-oxo-(2235-46-3)
EPA Substance Registry System	Butanamide, N,N-diethyl-3-oxo- (2235-46-3)

Safety information for N,N-Diethylacetoacetamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.