Nitisinone
Synonym(s):Nitisinone;NTBC;2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione;2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione;Nitisone
- Molecular Weight: 0
- Update Date: 2023-04-23 13:52:06
What is Nitisinone?
Description
This reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase was discovered by Swedish Orphan and is comarketed by Apoteket AB and Rare Disease Therapeutics. It is used as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1 (HT-1) disease.
The Uses of Nitisinone
Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.
The Uses of Nitisinone
Treatment of hereditary tyrosinemia.
brand name
. Orfadin (Swedish Orphan).
Synthesis
Nitisinone (17) was synthesized in one step by reacting 2-nitro-4-trifluoromethylbenzoyl chloride (153) with cyclohexane-1, 3-dione (154) in the presence of TEA and trimethylsilylcyanide or 2-cyano-2- (trimethylsilyloxy)propane.
Properties of Nitisinone
| Melting point: | 129-131°C |
| storage temp. | -20°C Freezer |
| solubility | Acetontrile (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | Light Brown to Brown |
Safety information for Nitisinone
Computed Descriptors for Nitisinone
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