NICLOFOLAN
- CAS NO.：10331-57-4
- Empirical Formula: C12H6Cl2N2O6
- Molecular Weight: 345.09
- MDL number: MFCD00867407
- EINECS: 233-720-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-12 15:35:02
What is NICLOFOLAN?
Chemical properties
Orange-yellow crystalline powder. Melting point 178-182 ℃. Soluble in acetone, glacial acetic acid and sodium hydroxide solution, slightly soluble in water and ethanol.
The Uses of NICLOFOLAN
Niclofolan can be used as deworming drug and anti-creep drug. It is used for prevention and treatment of hepatic chioniasis of cattle and sheep.
Definition
ChEBI: Niclofolan is a polychlorobiphenyl.
Synthesis
Niclofolan is obtained by nitration of 5,5 '-dichloro-2, 2' dihydroxybiphenyl. The nitration was carried out in acetic acid at a temperature not exceeding 20℃. Then activated carbon was added for reflux decolorization for 1h. The filter was pumped with a nitrate filter rod. The filtrate was cooled below 15℃ and crystallized. Dinitrochlorophenol was obtained by filtration, washing with acetic acid and drying. The yield is 60%.
Properties of NICLOFOLAN
| Boiling point: | 251.5°C (rough estimate) |
| Density | 1.8594 (rough estimate) |
| refractive index | 1.7350 (estimate) |
| pka | 4.34±0.40(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| EPA Substance Registry System | Niclofolan (10331-57-4) |
Safety information for NICLOFOLAN
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P391:Collect spillage. Hazardous to the aquatic environment P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P501:Dispose of contents/container to..… |
Computed Descriptors for NICLOFOLAN
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