NDT 9513727

CAS NO.：439571-48-9
Empirical Formula: C36H35N3O4
Molecular Weight: 573.68
MDL number: MFCD22683794
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 10:31:43

What is NDT 9513727?

Description

NDT 9513727 is a competitive antagonist of the C5a receptor (C5aR; IC₅₀ = 11.6 nM for human recombinant receptors) that has inverse agonist activity in a GTPγ[³⁵S] assay. It is selective for human recombinant over rat and mouse recombinant C5aRs (IC₅₀ = >10 μM for both) but does have activity at macaque and gerbil receptors (IC₅₀s = 7.3 and 6.4 nM, respectively). NDT 9513727 inhibits degranulation in U937 cells stimulated with C5a (IC₅₀ = 7.1 nM). It also prevents neutropenia induced by human recombinant C5a in gerbils (ED₅₀ = 2.2 mg/kg) and in cynomolgus macaques when administered at doses of 5 and 25 mg/kg.

The Uses of NDT 9513727

NDT 9513727 is a selective, and potent inverse agonist of the human C5aR. NDT 9513727 has been shown to effectively inhibit C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo. These results suggest that NDT 9513727 is a promising candidate for the treatment of human inflammatory diseases.

Storage

Store at +4°C

Properties of NDT 9513727

Boiling point:	723.1±62.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 100 mM; Ethanol: 100 mM
form	A solid
pka	6.69±0.50(Predicted)
color	White to yellow

Safety information for NDT 9513727

Computed Descriptors for NDT 9513727

New Products

Pentadecanoic acid 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 2-Bromo-5-Iodopyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile Tetrahydropyranyl-4-acetic acid Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside 5-fluoro-1,3-benzodioxole 2-Bromo-6-fluoroaniline 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-one