N3-PEG3-tBu
- CAS NO.：252881-73-5
- Empirical Formula: C13H25N3O5
- Molecular Weight: 303.3547
- MDL number: MFCD22201543
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-14 17:29:05
What is N3-PEG3-tBu?
Description
Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
The Uses of N3-PEG3-tBu
Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides.
Biological Activity
N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Properties of N3-PEG3-tBu
| form | Liquid |
| color | Colorless to light yellow |
Safety information for N3-PEG3-tBu
Computed Descriptors for N3-PEG3-tBu
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