N-Methyl-N-(trimethylsilyl)acetamide

Chemical properties

clear light yellow liquid

The Uses of N-Methyl-N-(trimethylsilyl)acetamide

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:???????

• Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.???????
• Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

General Description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).

Purification Methods

N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]