N-Methyl-N-(trimethylsilyl)acetamide
Synonym(s):MSA
- CAS NO.：7449-74-3
- Empirical Formula: C6H15NOSi
- Molecular Weight: 145.27
- MDL number: MFCD00040758
- EINECS: 231-217-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:20:21
What is N-Methyl-N-(trimethylsilyl)acetamide?
Chemical properties
clear light yellow liquid
The Uses of N-Methyl-N-(trimethylsilyl)acetamide
N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:???????
- Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.???????
- Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.
General Description
N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).
Purification Methods
N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]
Properties of N-Methyl-N-(trimethylsilyl)acetamide
| Boiling point: | 159-161 °C(lit.) |
| Density | 0.904 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | 48 °C |
| storage temp. | -20°C |
| pka | -0.11±0.70(Predicted) |
| form | lyophilized powder |
| color | Clear light yellow |
| Specific Gravity | 0.906 |
| Sensitive | Moisture Sensitive |
| BRN | 506975 |
| CAS DataBase Reference | 7449-74-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3) |
| EPA Substance Registry System | Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3) |
Safety information for N-Methyl-N-(trimethylsilyl)acetamide
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for N-Methyl-N-(trimethylsilyl)acetamide
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