N-(Hydroxymethyl)acetamide
- CAS NO.：625-51-4
- Empirical Formula: C3H7NO2
- Molecular Weight: 89.09
- MDL number: MFCD00014417
- EINECS: 210-897-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-11-04 17:04:02
What is N-(Hydroxymethyl)acetamide?
Chemical properties
white to light yellow crystalline powder
The Uses of N-(Hydroxymethyl)acetamide
N-(Hydroxymethyl)acetamide (cas# 625-51-4) is used as a catalyst in the method for manufacturing sol-gel silica particles method for manufacturing coating substrate coated with silica particles.
The Uses of N-(Hydroxymethyl)acetamide
Antiseptic, disinfectant especially for surgical instruments.
Purification Methods
Recrystallise it from freshly distilled Me2CO, wash the crystals with dry Et2O and dry them in a vacuum desiccator over P2O5. RF 0.4 on paper chromatography with CHCl3/EtOH (2:8) as solvent and developed with ammoniacal AgNO3. It also crystallises in needles from EtOAc containing a few drops of Me2CO. It is hygroscopic and should be stored under dry conditions. [Bachmann et al. J Am Chem Soc 73 2775 1951, Walter et al. Chem Ber 99 3204 1966, Einhorn & Ladisch Justus Liebigs Ann Chem 343 265 1905, Beilstein 2 IV 405.]
Properties of N-(Hydroxymethyl)acetamide
| Melting point: | 48-52 °C |
| Boiling point: | 165.17°C (rough estimate) |
| Density | 1.14 |
| refractive index | 1.4368 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Sparingly, Sonicated), DMSO (Slightly), Methanol (Slightly) |
| pka | 13.28±0.10(Predicted) |
| form | Crystalline |
| color | White to Off-White Low-Melting |
| Water Solubility | Soluble |
| Sensitive | Hygroscopic |
| Merck | 14,4242 |
| BRN | 506226 |
| CAS DataBase Reference | 625-51-4(CAS DataBase Reference) |
Safety information for N-(Hydroxymethyl)acetamide
Computed Descriptors for N-(Hydroxymethyl)acetamide
| InChIKey | HWJHZLJIIWOTGZ-UHFFFAOYSA-N |
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