N-HYDROXYBUTYRAMIDINE

CAS NO.：27620-10-6
Empirical Formula: C4H10N2O
Molecular Weight: 102.14
MDL number: MFCD05663152
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-16 08:28:57

What is N-HYDROXYBUTYRAMIDINE?

Description

N-hydroxybutyramidine is a kind of pharmaceutical intermediate, which can be prepared by the reaction of butyronitrile and hydroxylamine hydrochloride. It has been reported in the literature that it can be used to prepare (PI3) inhibitors.

What are the applications of Application

N-hydroxybutyramidine is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in the laboratory research and development process and the chemical and pharmaceutical synthesis process.

Preparation

A solution of a mixture of butyronitrile, NaOH and hydroxylamine hydrochloride in 95% ethanol and water was refluxed Heat for 12 hours. The solvent was removed in vacuo, the oily residue was dissolved in chloroform , and insoluble NaCl was removed by filtration. The filtrate was concentrated in vacuo to give N-hydroxybutyramidine as a colorless oil.

Properties of N-HYDROXYBUTYRAMIDINE

Boiling point:	89 °C
color	Pale brown
CAS DataBase Reference	27620-10-6

Safety information for N-HYDROXYBUTYRAMIDINE

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.